This page can help you find out more about antipsychotics, their side-effects and stopping you medication. In fact, they are more likely to cause type 2 diabetes, weight gain, and tardive dyskinesia (a neurological disorder characterized by involuntary, repetitive body movements). Metabolic side effects (e.g., weight gain, insulin resistance), on the other hand, are more typical of second-generation antipsychotics. Extrapyramidal motor side effects.

However, evidence suggests that atypical antipsychotics are not as unencumbered by side effects as once believed. Many antipsychotics can increase the release of prolactin, which can lead to a number of acute side effects: sexual dysfunction, anovulation, inappropriate lactation (galactorrhea), and gynecomastia. In general, higher potency typical antipsychotics, such as haloperidol, are less sedating, less cardiotoxic, and less anticholinergic than low-potency agents but more likely to cause extrapyramidal side effects. Motor disturbances are the result of direct or indirect blockade of D2 receptors in the nigrostriatal dopaminergic pathway. Typical antipsychotics, also known as conventional antipsychotics or major tranquilizers, were first developed in the 1950s for the treatment of psychosis. BUY THIS AS A STUDY CARD. This is a complex, unpleasant, emotional state that often (though not always) leads to visible restlessness. If you experience psychosis as part of your illness, you may be offered antipsychotic medication. In response to the serious side effects of many typical antipsychotics, drug manufacturers developed another category referred to as atypical antipsychotics. The first antipsychotic drug in this class, chlorpromazine, was introduced more than 60 years ago . Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal. Compared to typical (first-generation) antipsychotics, the atypical antipsychotics have lower affinity for dopamine D2 receptors, and they also act at serotonin (5-HT) receptors (they are antagonists for these receptors). In schizophrenia, conventional or classic antipsychotics remain today the drugs of first choice in schizophrenia. Side effects of antipsychotic drugs As with all medicines, antipsychotics can produce side effects in some people. Why does D2 blockade result in side effects? Conventional antipsychotics block two types of chemical receptors in the brain – receptors for dopamine and serotonin. Classical antipsychotics versus atypical antipsychotics. When a typical antipsychotic which is a dopamine antagonist is prescribed, it cannot selectively block the D2 in the mesolimbic area while sparing the D2 receptors in other areas. Therefore, prescription of a D2 antagonist can block Dopamine receptors in other areas, resulting in side effects. Antipsychotics are a group of drugs that are used to treat schizophrenia and other mental illnesses, such as bipolar disorder, severe anxiety, or depression. Antipsychotics can be imperfectly divided … The side effects reportedly associated with the various atypical antipsychotics vary and are medication-specific. This is a complex, unpleasant, emotional state that often (though not always) leads to visible restlessness. Akathisia may be one of the most serious side effects of antipsychotics.

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